Mouse Genome Informatics
either: (involves: 101 * SEC) or (involves: 101 * C57BL * SEC)
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hematopoietic system
• reduced mean cell volume despite increased red cell numbers
• red cells of irregular size and shape with pitted surfaces and blebs are seen
• increase in the percentage of cells with flattened or doughnut (34.5%) shape compared to controls
• red cells are 75 - 80% the size of wild-type cells
• increase in the percentage of acanthocytes or cells with teardrop shape (6.2%) compared to controls

Mouse Models of Human Disease
Alpha-Thalassemia 604131 J:123943