Phenotypes Associated with This Genotype

Genotype
MGI:3720086

• Allelic Composition: Hba^b3(th)/Hba⁺
• Genetic Background: either: (involves: 101 * SEC) or (involves: 101 * C57BL * SEC)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hypochromic microcytic anemia ( J:123943 )

increased erythrocyte cell number ( J:123943 )

decreased hematocrit ( J:123943 )

decreased hemoglobin content ( J:123943 )

decreased mean corpuscular hemoglobin ( J:123943 )

decreased mean corpuscular volume ( J:123943 )

• reduced mean cell volume despite increased red cell numbers

anisocytosis ( J:123943 )

acanthocytosis ( J:86011 )

anisopoikilocytosis ( J:86011 )

• red cells of irregular size and shape with pitted surfaces and blebs are seen

dacryocytosis ( J:86011 )

leptocytosis ( J:86011 )

• increase in the percentage of cells with flattened or doughnut (34.5%) shape compared to controls

microcytosis ( J:123943 )

• red cells are 75 - 80% the size of wild-type cells

poikilocytosis ( J:86011 )

• increase in the percentage of acanthocytes or cells with teardrop shape (6.2%) compared to controls

reticulocytosis ( J:123943 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alpha thalassemia		DOID:1099	OMIM:604131	J:123943