Phenotypes Associated with This Genotype

Genotype
MGI:3720048

• Allelic Composition: Tbp^tm1.1Ees/Tbp^tm1.1Ees
• Genetic Background: B6.129X1(Cg)-Tbp^tm1.1Ees

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:77714 )

• 67% of surviving mice die prior to weaning

embryonic lethality during organogenesis, incomplete penetrance ( J:77714 )

• most recovered embryos are dying or resorbed between E10.5 and E12.5 91% of embryos are lost between E10.5 and E12.5

• however, survival can be increased by using Rag null mothers

embryo

placenta hemorrhage ( J:77714 )

• hemorrhages are evident in the placenta

immune system

hemophagocytosis ( J:77714 )

• hemophagocytosis is evident in the placenta

hematopoietic system

hemophagocytosis ( J:77714 )

• hemophagocytosis is evident in the placenta

homeostasis/metabolism

abnormal blood coagulation ( J:77714 )

• ~25% of placentas have regions showing mixing of maternal and embryonic blood, and clots of maternal blood are abundant

cardiovascular system

placenta hemorrhage ( J:77714 )

• hemorrhages are evident in the placenta

growth/size/body

fetal growth retardation ( J:77714 )

• prior to death pups exhibit varying degrees of growth retardation