Mouse Genome Informatics
ht
    Snrpntm2Alb/Snrpn+
involves: 129S7/SvEvBrd * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• when the allele is inherited paternally 45 to 50% of mice die prior to weaning
• however, when the allele is inherited maternally the offspring exhibit no abnormal postnatal lethality

growth/size
• when inherited paternally mice weigh an average of 2.18+/-0.30 g compared to wild-type mice that weigh 3.10+/-0.57 g (J:70275)
• when inherited maternally mice have normal weights (J:70275)
• when inherited paternally, all organs examined are smaller than in wild-type mice (J:70275)
• when inherited paternally, mice have decreased body weight compared to wild-type mice and Snrpntm2Alb/Snrpntm4Alb heterogyzotes (J:105289)
• when inherited paternally mice exhibit postnatal growth retardation
• however, when inherited maternally mice have normal growth rates

cellular
N
• methylation patterns associated with imprinting are normal (J:70275)

Mouse Models of Human Disease
OMIM IDRef(s)
Prader-Willi Syndrome; PWS 176270 J:70275