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Phenotypes Associated with This Genotype
Genotype
MGI:3719120
Allelic
Composition
Snrpntm2Alb/Snrpn+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snrpntm2Alb mutation (0 available); any Snrpn mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• when the allele is inherited paternally 45 to 50% of mice die prior to weaning
• however, when the allele is inherited maternally the offspring exhibit no abnormal postnatal lethality

growth/size/body
• when inherited paternally mice weigh an average of 2.18+/-0.30 g compared to wild-type mice that weigh 3.10+/-0.57 g (J:70275)
• when inherited maternally mice have normal weights (J:70275)
• when inherited paternally, all organs examined are smaller than in wild-type mice (J:70275)
• when inherited paternally, mice have decreased body weight compared to wild-type mice and Snrpntm2Alb/Snrpntm4Alb heterogyzotes (J:105289)
• when inherited paternally mice exhibit postnatal growth retardation
• however, when inherited maternally mice have normal growth rates

cellular
N
• methylation patterns associated with imprinting are normal

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Prader-Willi syndrome DOID:11983 OMIM:176270
J:70275


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory