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Phenotypes Associated with This Genotype
Genotype
MGI:3718910
Allelic
Composition
Apptm1Umu/Apptm1Umu
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm1Umu mutation (0 available); any App mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• behavioral defects (impaired grip strength, abnormal level and circadian distribution of activity, decreased exploratory behavior under aversive conditions, increased thigmotaxic behavior, reduced swim speed, and impaired spatial learning) seen in null mice are not present in homozygous knock-in mice

nervous system
N
• brain weight and long term potentiation are normal, unlike in homozygous null mice

growth/size/body
N
• body weight is normal, unlike in homozygous null mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory