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Phenotypes Associated with This Genotype
Genotype
MGI:3718115
Allelic
Composition
Tg(Camk2a-MAPT*R406W)748Atak/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mortality of transgenic mice is higher than in non-transgenic littermates

behavior/neurological
• in contextual testing 24 hours after conditioning, mutants and control mice show similar levels of freezing; however, in testing conducted 15 days after conditioning, transgenic mice show significantly lower levels of freezing than control littermates suggesting impaired establishment of permanent memory
• transgenic mice show reduced levels of fear response in a cued conditioning paradigm, as shown by lower levels of freezing after foot shocks

nervous system
• congophilic tau inclusions are seen in a subset of forebrain neurons in aged mice (18 months); these inclusions are analogous to neurofibrillary tangles seen in humans
• a significant decrease in prepulse inhibition of the startle response in aged mice relative to controls

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
frontotemporal dementia DOID:9255 OMIM:600274
OMIM:600795
J:100958


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/05/2019
MGI 6.13
The Jackson Laboratory