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Phenotypes Associated with This Genotype
involves: C57BL/6 * SJL
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phenotype observed in females
phenotype observed in males
N normal phenotype
• mortality of transgenic mice is higher than in non-transgenic littermates

• in contextual testing 24 hours after conditioning, mutants and control mice show similar levels of freezing; however, in testing conducted 15 days after conditioning, transgenic mice show significantly lower levels of freezing than control littermates suggesting impaired establishment of permanent memory
• transgenic mice show reduced levels of fear response in a cued conditioning paradigm, as shown by lower levels of freezing after foot shocks

nervous system
• congophilic tau inclusions are seen in a subset of forebrain neurons in aged mice (18 months); these inclusions are analogous to neurofibrillary tangles seen in humans
• a significant decrease in prepulse inhibition of the startle response in aged mice relative to controls

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
frontotemporal dementia DOID:9255 OMIM:600274

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory