Phenotypes Associated with This Genotype

Genotype
MGI:3717649

• Allelic Composition: Ptpn6^m1Btlr/Ptpn6^m1Btlr
• Genetic Background: C57BL/6J-Ptpn6^m1Btlr/Mmucd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Chronic inflammation in Ptpn6^m1Btlr/Ptpn6^m1Btlr mice

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:142845 )

• inoculation with 5x10⁵ CFUs leads to the death of all controls while killing none of the mutant mice

limbs/digits/tail

ulcerated autopod ( J:142845 )

• plantar surfaces of the feet develop inflamed, raw, weeping lesions in 90% of mice between 10 and 25 weeks of age

• this inflammation leads to thickening of the epidermis, microabscesses in the epidermal and dermal layers, and a neutrophilic infiltrate in the dermal layer

• cellularity of the bone marrow adjacent to lesions is increased

• this phenotype is dependent on the presence of microbes in the housing

immune system

enlarged spleen ( J:94077 , J:142845 )

• splenomegaly (J:94077)

• occurs in mice after 6 weeks of age with a mean weight of 98 mg compared to 68 mg (J:142845)

• this phenotype is dependent on the presence of microbes in the housing (J:142845)

decreased mature B cell number ( J:142845 )

• there is a 40%-50% reduction in the number of mature B cells in the peripheral blood and bone marrow

abnormal myeloid leukocyte morphology ( J:142845 )

• there are an increased number of myeloid cells in the spleen and bone marrow of mice over 7 weeks of age

increased neutrophil cell number ( J:142845 )

• increased numbers of neutrophils are found in the spleen and bone marrow of mice over 7 weeks of age

increased IgM level ( J:142845 )

• mean serum IgM levels are about 2.5 fold higher than in controls

• this phenotype is dependent on the presence of microbes in the housing

increased anti-chromatin antibody level ( J:142845 )

• significant levels of anti-chromatin IgM (about 6 micrograms/ml) and IgG (3 micrograms/ml) are detectable in the sera of mice over 4 months of age

increased inflammatory response ( J:94077 )

• inflammation of the paws

salivary gland inflammation ( J:142845 )

• salivary glands contain hematopoietic cell infiltrates

• this phenotype is dependent on the presence of microbes in the housing

lung inflammation ( J:142845 )

• the lungs contain hematopoietic cell infiltrates

• this phenotype is dependent on the presence of microbes in the housing

decreased susceptibility to bacterial infection ( J:142845 )

• mice have a diminished bacterial burden 2 and 3 days after inoculation with Listeria monocytogenes

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:142845 )

• inoculation with 5x10⁵ CFUs leads to the death of all controls while killing none of the mutant mice

hematopoietic system

enlarged spleen ( J:94077 , J:142845 )

• splenomegaly (J:94077)

• occurs in mice after 6 weeks of age with a mean weight of 98 mg compared to 68 mg (J:142845)

• this phenotype is dependent on the presence of microbes in the housing (J:142845)

increased erythroid progenitor cell number ( J:142845 )

• increase numbers of erythroid cells are found in the spleen though numbers are reduced in the bone marrow

decreased mature B cell number ( J:142845 )

• there is a 40%-50% reduction in the number of mature B cells in the peripheral blood and bone marrow

abnormal myeloid leukocyte morphology ( J:142845 )

• there are an increased number of myeloid cells in the spleen and bone marrow of mice over 7 weeks of age

increased neutrophil cell number ( J:142845 )

• increased numbers of neutrophils are found in the spleen and bone marrow of mice over 7 weeks of age

increased IgM level ( J:142845 )

• mean serum IgM levels are about 2.5 fold higher than in controls

• this phenotype is dependent on the presence of microbes in the housing

respiratory system

lung inflammation ( J:142845 )

• the lungs contain hematopoietic cell infiltrates

• this phenotype is dependent on the presence of microbes in the housing

digestive/alimentary system

salivary gland inflammation ( J:142845 )

• salivary glands contain hematopoietic cell infiltrates

• this phenotype is dependent on the presence of microbes in the housing

endocrine/exocrine glands

salivary gland inflammation ( J:142845 )

• salivary glands contain hematopoietic cell infiltrates

• this phenotype is dependent on the presence of microbes in the housing

integument

integument phenotype ( J:94077 )

N • normal coat

growth/size/body

enlarged spleen ( J:94077 , J:142845 )

• splenomegaly (J:94077)

• occurs in mice after 6 weeks of age with a mean weight of 98 mg compared to 68 mg (J:142845)

• this phenotype is dependent on the presence of microbes in the housing (J:142845)