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Phenotypes Associated with This Genotype
Genotype
MGI:3717244
Allelic
Composition
Artm1.1Jdz/Y
Genetic
Background
B6.129X1-Artm1.1Jdz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Artm1.1Jdz mutation (0 available); any Ar mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• at 8 weeks, hemizygous mutant males show a marked reduction of the total number of germ cells in their seminiferous tubules, although the number of spermatogonia is apparently normal
• no spermatozoa are detected at 8 weeks of age
• at 8 weeks, spermatogenesis is incomplete, as primary spermatocytes are readily observed, but no secondary spermatocytes, spermatids or spermatozoa are detected
• spermatogenesis is arrested at meiosis I
• at 8 weeks of age
• at 8 weeks of age
• at 8 weeks of age, the tunica propria is more prominent in the mutant testis with 2-3 layers visible relative to one layer found in wild-type males
• although Leydig cells are present in similar numbers to those found in wild-type testes, the interstitial connective tissue appears to be more pronounced in mutant testes
• at 8 weeks, the seminiferous tubules in mutant testis are smaller in diameter relative to wild-type controls
• at 8 weeks of age, mutant testes are smaller than wild-type
• at 8 weeks of age, the testis mass of hemizygous mutant males is reduced by 95% relative to wild-type control males
• mutant testes are located intra-abdominally
• hemizygous mutant males display female external genitalia

growth/size/body
• at 8 weeks and 10 to 25 weeks hemizygous mutant males weigh less than wild-type males; their mean body weight is intermediate between wild-type male and female control littermates
• contrary to expectation, hemizygous mutant males do not become heavier than wild-type control males with increasing age

homeostasis/metabolism
• at 9 weeks of age, serum testosterone levels of hemizygous mutant males are reduced relative to wild-type control littermates

endocrine/exocrine glands
• at 8 weeks of age
• at 8 weeks of age
• at 8 weeks of age, the tunica propria is more prominent in the mutant testis with 2-3 layers visible relative to one layer found in wild-type males
• although Leydig cells are present in similar numbers to those found in wild-type testes, the interstitial connective tissue appears to be more pronounced in mutant testes
• at 8 weeks, the seminiferous tubules in mutant testis are smaller in diameter relative to wild-type controls
• at 8 weeks of age, mutant testes are smaller than wild-type
• at 8 weeks of age, the testis mass of hemizygous mutant males is reduced by 95% relative to wild-type control males
• mutant testes are located intra-abdominally

Mouse Models of Human Disease
OMIM ID Ref(s)
Androgen Insensitivity Syndrome; AIS 300068 J:123057


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory