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Phenotypes Associated with This Genotype
Genotype
MGI:3717132
Allelic
Composition		 Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Pdgfratm2Sor/Pdgfra+
Genetic
Background		 involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arid5bGt(ROSA)75Sor mutation (1 available); any Arid5b mutation (139 available)
Pdgfratm2Sor mutation (0 available); any Pdgfra mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal frontal bone morphology ( J:117491 )
• distance between the frontal bones is increased compared with Arid5bGt(ROSA)75Sor homozygotes and often accompanied by outgrowth of the interfrontal bone
cleft palate ( J:117491 )
• reduced or completely cleft palates are present in all mice
broad snout ( J:117491 )
• snout is shorter and wider than in Arid5bGt(ROSA)75Sor homozygotes
short snout ( J:117491 )
• snout is shorter and wider than in Arid5bGt(ROSA)75Sor homozygotes

skeleton
abnormal skeleton morphology ( J:117491 )
• skeletal defects are more severe than in Arid5bGt(ROSA)75Sor homozygotes
abnormal frontal bone morphology ( J:117491 )
• distance between the frontal bones is increased compared with Arid5bGt(ROSA)75Sor homozygotes and often accompanied by outgrowth of the interfrontal bone

digestive/alimentary system
cleft palate ( J:117491 )
• reduced or completely cleft palates are present in all mice

growth/size/body
abnormal frontal bone morphology ( J:117491 )
• distance between the frontal bones is increased compared with Arid5bGt(ROSA)75Sor homozygotes and often accompanied by outgrowth of the interfrontal bone
short premaxilla ( J:117491 )
short maxilla ( J:117491 )
short nasal bone ( J:117491 )
cleft palate ( J:117491 )
• reduced or completely cleft palates are present in all mice
complete cleft palate ( J:117491 )
broad snout ( J:117491 )
• snout is shorter and wider than in Arid5bGt(ROSA)75Sor homozygotes
short snout ( J:117491 )
• snout is shorter and wider than in Arid5bGt(ROSA)75Sor homozygotes

respiratory system

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/29/2025
MGI 6.24 		The Jackson Laboratory