Analysis Tools
immune system
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• mice have smaller medullas compared to wild-type mice
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• at 4 weeks, thymus have 50% of the cells found in wild-type mice
• at 8 weeks, thymus have 85% of the cells found in wild-type mice
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• mice accumulate CD44-CD25+ double negative cells and fail to undergo TCR-rearrangement
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• thymocytes undergo increased apoptosis when compared with wild-type mice
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• at 4 weeks, spleens have 50% of the cells found in wild-type mice
• at 8 weeks, spleens have 85% of the cells found in wild-type mice
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• T and B cell zones are smaller than in wild-type mice
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cellular
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• the G1 cell cycle checkpoint in mouse embryonic fibroblast cells is defective following gamma and UV irradiation
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• mouse embryonic fibroblast cells display increased proliferation
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hematopoietic system
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• mice have smaller medullas compared to wild-type mice
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• at 4 weeks, thymus have 50% of the cells found in wild-type mice
• at 8 weeks, thymus have 85% of the cells found in wild-type mice
|
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• mice accumulate CD44-CD25+ double negative cells and fail to undergo TCR-rearrangement
|
|
• thymocytes undergo increased apoptosis when compared with wild-type mice
|
|
• at 4 weeks, spleens have 50% of the cells found in wild-type mice
• at 8 weeks, spleens have 85% of the cells found in wild-type mice
|
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• T and B cell zones are smaller than in wild-type mice
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endocrine/exocrine glands
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• mice have smaller medullas compared to wild-type mice
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• at 4 weeks, thymus have 50% of the cells found in wild-type mice
• at 8 weeks, thymus have 85% of the cells found in wild-type mice
|
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• thymocytes undergo increased apoptosis when compared with wild-type mice
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