Phenotypes Associated with This Genotype

Genotype
MGI:3716846

• Allelic Composition: Apoe^shl/Apoe^shl
• Genetic Background: involves: C57BL/6 * KOR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Xanthoma of Apoe^shl/Apoe^shl mice

mortality/aging

premature death ( J:54051 )

• mice die at 14 months with females dying slightly earlier than males

homeostasis/metabolism

increased circulating cholesterol level ( J:54051 )

• cholesterol levels are high prior to weaning and decrease

xanthoma ( J:54051 )

• detected as early as 4 weeks in palms and distal forelimb extremities at 3 months, lesions are apparent at periocular and chest regions at 6 months, lesions are present in a wide range of skin areas other than head and back

• at 3 months, lesions are apparent at periocular and chest regions

• at 6 months, lesions are present in a wide range of skin areas other than head and back

cardiovascular system

atherosclerotic lesions ( J:54051 )

• atherosclerotic lesions with cholesterol-clefts and deposits in the aortic wall

integument

alopecia ( J:54051 )

• associated with xanthoma lesions on chest