Phenotypes Associated with This Genotype

Genotype
MGI:3716595

• Allelic Composition: Usp8^tm1.2Kpk/Usp8^tm1.2Kpk
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:122732 )

• homozygotes can be recovered at E9.5, but embryos are severely abnormal

embryo

abnormal embryo development ( J:122732 )

• embryos appear grossly disorganized at E9.5

abnormal dorsal-ventral axis patterning ( J:122732 )

• embryos fail to initiate ventral folding

embryonic growth retardation ( J:122732 )

• at E9.5, embryos are dramatically growth retarded

growth/size/body

embryonic growth retardation ( J:122732 )

• at E9.5, embryos are dramatically growth retarded

cardiovascular system

abnormal heart development ( J:122732 )

• embryos do not initiate ventral folding, a prerequistite for heart formation