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Phenotypes Associated with This Genotype
Genotype
MGI:3716137
Allelic
Composition
Ins2tm1Jja/Ins2tm1Jja
Genetic
Background
NOD.129S2-Ins2tm1Jja
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ins2tm1Jja mutation (4 available); any Ins2 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Severe insulitis in Ins2tm1Jja/Ins2tm1Jja mice and lack of insulitis in Ins1tm1Jja/Ins1tm1Jja mice

homeostasis/metabolism
• development of diabetes is accelerated compared to wild-type controls; all but one female develop diabetes between 7 and 15 weeks of age

immune system
• severe insulitis with primarily intraislet infiltrates
• both males and females have higher peak levels of insulin autoantibodies than wild-type

endocrine/exocrine glands
• severe insulitis with primarily intraislet infiltrates

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:85309


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory