Mouse Genome Informatics
hm
    Ins2tm1Jja/Ins2tm1Jja
NOD.129S2-Ins2tm1Jja
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Severe insulitis in Ins2tm1Jja/Ins2tm1Jja mice and lack of insulitis in Ins1tm1Jja/Ins1tm1Jja mice

homeostasis/metabolism
• development of diabetes is accelerated compared to wild-type controls; all but one female develop diabetes between 7 and 15 weeks of age

immune system
• severe insulitis with primarily intraislet infiltrates
• both males and females have higher peak levels of insulin autoantibodies than wild-type

endocrine/exocrine glands
• severe insulitis with primarily intraislet infiltrates

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:85309