Phenotypes for Apc Ppard MGI:3715726 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Apc^Min/Apc^Min Ppard^tm1.1Rev/Ppard^tm1.1Rev
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (154 available)
Ppard^tm1.1Rev mutation (0 available); any Ppard mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

intestine polyps ( J:73557 )

• mice harbor conspicuous intestinal polyps; average number is similar to wild-type and heterozygous mice

• there is a decrease in large diameter polyps relative to controls, while small polyp number is similar between all groups

colon polyps ( J:73557 )

• mice harbor conspicuous colonic polyps

increased intestinal adenoma incidence ( J:73557 )

• polyps are low grade noninvasive tubular adenomas

neoplasm

increased intestinal adenoma incidence ( J:73557 )

• polyps are low grade noninvasive tubular adenomas

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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