Mouse Genome Informatics
hm
    Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• 50% die by around 11 months of age and none survive beyond 16 months of age

endocrine/exocrine glands
• weights of thyroid glands increase as mice age

tumorigenesis
• spontaneously develop follicular thyroid carcinoma through the pathological progression of hyperplasia, capsular and vascular invasion, anaplasia, and eventually metastasis to the lung but not the lymph nodes

Mouse Models of Human Disease
OMIM IDRef(s)
Thyroid Carcinoma, Follicular; FTC 188470 J:92629