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Phenotypes Associated with This Genotype
Genotype
MGI:3715723
Allelic
Composition
Thrbtm1.1Syc/Thrbtm1.1Syc
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thrbtm1.1Syc mutation (0 available); any Thrb mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50% die by around 11 months of age and none survive beyond 16 months of age

endocrine/exocrine glands
• weights of thyroid glands increase as mice age
• spontaneously develop follicular thyroid carcinoma through the pathological progression of hyperplasia, capsular and vascular invasion, anaplasia, and eventually metastasis to the lung but not the lymph nodes

neoplasm
• spontaneously develop follicular thyroid carcinoma through the pathological progression of hyperplasia, capsular and vascular invasion, anaplasia, and eventually metastasis to the lung but not the lymph nodes


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory