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Phenotypes Associated with This Genotype
Genotype
MGI:3715723
Allelic
Composition
Thrbtm1.1Syc/Thrbtm1.1Syc
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thrbtm1.1Syc mutation (0 available); any Thrb mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50% die by around 11 months of age and none survive beyond 16 months of age (J:92629)
• 50% die by around 11 months of age and none survive beyond 16 months of age (J:92629)

endocrine/exocrine glands
• weights of thyroid glands increase as mice age (J:92629)
• weights of thyroid glands increase as mice age (J:92629)

tumorigenesis
• spontaneously develop follicular thyroid carcinoma through the pathological progression of hyperplasia, capsular and vascular invasion, anaplasia, and eventually metastasis to the lung but not the lymph nodes (J:92629)
• spontaneously develop follicular thyroid carcinoma through the pathological progression of hyperplasia, capsular and vascular invasion, anaplasia, and eventually metastasis to the lung but not the lymph nodes (J:92629)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory