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Phenotypes Associated with This Genotype
Genotype
MGI:3715607
Allelic
Composition
Thrbtm1.1Syc/Thrb+
Genetic
Background
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thrbtm1.1Syc mutation (0 available); any Thrb mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Histology of thyroid glands of wild-type, Thrbtm1.1Syc/Thrb+ and Thrbtm1.1Syc/Thrbtm1.1Syc mice.

endocrine/exocrine glands
• increase in the size of individual follicles of the thyroid gland
• thyroid gland is about 2.4-fold larger than in wild-type
• the increase in TSH level despite increases in thyroid hormone levels, indicate that the pituitary is resistant to the action of thyroid hormone

homeostasis/metabolism
• TSH is 2.1-fold higher than in wild-type
• 2.5-fold higher circulating T4 concentration than in wild-type
• 2-fold increase in the circulating total T3 concentration

skeleton
• femurs are 4% shorter
• tibias are 5% shorter

limbs/digits/tail
• femurs are 4% shorter
• tibias are 5% shorter

nervous system
• the increase in TSH level despite increases in thyroid hormone levels, indicate that the pituitary is resistant to the action of thyroid hormone

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
thyroid hormone resistance syndrome DOID:11633 OMIM:188570
OMIM:274300
J:65885


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/20/2017
MGI 6.10
The Jackson Laboratory