Mouse Genome Informatics
ht
    Thrbtm1.1Syc/Thrb+
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Histology of thyroid glands of wild-type, Thrbtm1.1Syc/Thrb+ and Thrbtm1.1Syc/Thrbtm1.1Syc mice.

endocrine/exocrine glands
• increase in the size of individual follicles of the thyroid gland
• thyroid gland is about 2.4-fold larger than in wild-type
• the increase in TSH level despite increases in thyroid hormone levels, indicate that the pituitary is resistant to the action of thyroid hormone

homeostasis/metabolism
• TSH is 2.1-fold higher than in wild-type
• 2.5-fold higher circulating T4 concentration than in wild-type
• 2-fold increase in the circulating total T3 concentration

skeleton
• femurs are 4% shorter
• tibias are 5% shorter

limbs/digits/tail
• femurs are 4% shorter
• tibias are 5% shorter

nervous system
• the increase in TSH level despite increases in thyroid hormone levels, indicate that the pituitary is resistant to the action of thyroid hormone

Mouse Models of Human Disease
OMIM IDRef(s)
Thyroid Hormone Resistance, Generalized, Autosomal Dominant; GRTH 188570 J:65885