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Phenotypes Associated with This Genotype
Genotype
MGI:3715607
Allelic
Composition
Thrbtm1.1Syc/Thrb+
Genetic
Background
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thrbtm1.1Syc mutation (0 available); any Thrb mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Histology of thyroid glands of wild-type, Thrbtm1.1Syc/Thrb+ and Thrbtm1.1Syc/Thrbtm1.1Syc mice.

endocrine/exocrine glands
• increase in the size of individual follicles of the thyroid gland
• thyroid gland is about 2.4-fold larger than in wild-type
• the increase in TSH level despite increases in thyroid hormone levels, indicate that the pituitary is resistant to the action of thyroid hormone

homeostasis/metabolism
• TSH is 2.1-fold higher than in wild-type
• 2.5-fold higher circulating T4 concentration than in wild-type
• 2-fold increase in the circulating total T3 concentration

skeleton
• femurs are 4% shorter
• tibias are 5% shorter

limbs/digits/tail
• femurs are 4% shorter
• tibias are 5% shorter

nervous system
• the increase in TSH level despite increases in thyroid hormone levels, indicate that the pituitary is resistant to the action of thyroid hormone


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory