Phenotypes Associated with This Genotype

Genotype
MGI:3715311

• Allelic Composition: Plcb3^tm1Dwu/Plcb3^tm1Dwu
• Genetic Background: involves: CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

analgesia ( J:57478 )

• mutants are more sensitive to antinociceptive effects of morphine than wild-type mice

• mutants show a 5-fold increased sensitivity to morphine as measured by antinociception in hot plate tail-flick assay

homeostasis/metabolism

abnormal calcium ion homeostasis ( J:66819 )

• in response to somatostatin, there is no influx of calcium measured in aortic smooth muscle cells in mutants compared to wild-type cells which show show an increased calcium level