Mouse Genome Informatics
hm
    Tubtub/Tubtub
C57BL/6J-Tubtub
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
growth/size/body
• the increase in weight is due to excess adipose tissue associated with all fat deposits
• increased body weight first becomes obvious at 3-4 months of age in males and 4-6 months in females

adipose tissue
• the increase in weight is due to excess adipose tissue associated with all fat deposits

homeostasis/metabolism
• plasma immunoreactive insulin is increased to 2 times the normal prior to signs of obesity
• plasma insulin concentrations increase gradually through out life
• however, blood sugar levels are normal up to 9 months of age, the oldest mice tested
• liver glycogen is slightly increased

endocrine/exocrine glands
• islets of Langerhans are moderately enlarged

immune system
• islets of Langerhans show indication of hyperactivity in the later stages

liver/biliary system
• total liver lipids range from 2-3 times the normal

Mouse Models of Human Disease
OMIM IDRef(s)
Obesity 601665 J:13772