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Phenotypes Associated with This Genotype
Genotype
MGI:3715252
Allelic
Composition
Tubtub/Tubtub
Genetic
Background
C57BL/6J-Tubtub
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tubtub mutation (3 available); any Tub mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• increased body weight first becomes obvious at 3-4 months of age in males and 4-6 months in females

adipose tissue
• the increase in weight is due to excess adipose tissue associated with all fat deposits

homeostasis/metabolism
• plasma immunoreactive insulin is increased to 2 times the normal prior to signs of obesity
• plasma insulin concentrations increase gradually through out life
• however, blood sugar levels are normal up to 9 months of age, the oldest mice tested
• liver glycogen is slightly increased

endocrine/exocrine glands
• islets of Langerhans are moderately enlarged

immune system
• islets of Langerhans show indication of hyperactivity in the later stages

liver/biliary system
• liver glycogen is slightly increased
• total liver lipids range from 2-3 times the normal

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:13772


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory