Mouse Genome Informatics
hm
    Gnat2cpfl3/Gnat2cpfl3
ALS/LtJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
vision/eye
• dilated retinal veins and slightly constricted arterioles are observed in 8 month old mice
• outer segments are vacuolated by 27 weeks of age
• reduced labeling for alpha-transducin in cone outer segments as determined by immunocytochemistry, however, PNA staining reveals a normal number of cone outer segments
• photopic responses are 25% of normal by 4 weeks of age and completely diminished by 9 months
• scotopic (rod) responses show some diminution, but are near normal by 9 months of age

nervous system
• outer segments are vacuolated by 27 weeks of age
• reduced labeling for alpha-transducin in cone outer segments as determined by immunocytochemistry, however, PNA staining reveals a normal number of cone outer segments

cardiovascular system
• dilated retinal veins and slightly constricted arterioles are observed in 8 month old mice

Mouse Models of Human Disease
OMIM IDRef(s)
Achromatopsia 4; ACHM4 613856 J:122428