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Phenotypes Associated with This Genotype
Genotype
MGI:3715158
Allelic
Composition
Ubctm1Rrk/Ubctm1Rrk
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ubctm1Rrk mutation (0 available); any Ubc mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• non-Mendelian ratios are first found at E12.5 and by E16.5 to E17.5 no pups are recovered

cellular
• mouse embryonic cells exhibit reduced length of G1 phase and increased G2/M phase
• without prior conditioning, mouse embryonic cells exhibit decreased viability when heat-shocked for 15 or 45 minutes
• increased viability following heat-shock was reduced when mouse embryonic cells were preconditioned
• mouse embryonic cells exhibit reduced proliferation
• mouse embryonic cells exhibit premature senescence

liver/biliary system
• at E13.5, the fetal liver mass is reduced in size with reduced hepatic parenchyma and enlarged venous sinusoids
• at E13.5, hepatocyte precursors are present in reduced numbers

embryo
• at E13.5, mice are smaller in size
• at E13.5, hematopoietic precursors are present in reduced numbers

growth/size/body
• at E13.5, mice are smaller in size

hematopoietic system
• at E13.5, hematopoietic precursors are present in reduced numbers


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory