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Phenotypes Associated with This Genotype
Genotype
MGI:3714608
Allelic
Composition		 Dp(4D4Mit190-D4Mit51)1Aam/0
Trp53tm1Brd/Trp53+
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dp(4D4Mit190-D4Mit51)1Aam mutation (0 available); any Dp(4D4Mit190-D4Mit51)1Aam mutation (0 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:121726 )
• some mice die prior to weaning

embryo
abnormal embryo development ( J:121726 )
• defects in development are less severe than in Dp(4D4Mit190-D4Mit51)1AAM heterozygotes

growth/size/body
decreased body size ( J:121726 )
• some mice are runted

behavior/neurological
ataxia ( J:121726 )
• some mice develop ataxia

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory