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Phenotypes Associated with This Genotype
Genotype
MGI:3714013
Allelic
Composition
Acetm6Keb/Acetm6Keb
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acetm6Keb mutation (0 available); any Ace mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• the number of white blood cells in tumor blood vessels is increased and includes monocyte-like and phagocytic cells
• Background Sensitivity: after infection with B16-F10 melanoma cells, tumor size is reduced on a 129/C57BL/6 background to 90+/-18mm3 compared to 540+/-83mm3 in wild-type mice
• reduced tumor size is observed following infection with B16-LS9 cells or mouse lymphoma cell line EL4
• however, treatment with captopril or anti-CD8+ antibodies reverts tumor growth to wild-type size

immune system
• CD8+ T cell numbers are increased following exposure to two B16-F10-specific epitopes or mouse lymphoma cell line EL4
• IL-12 levels are increased following treatment with LPs or LPS and interferon-gamma
• IL-10 levels are decreased following treatment with melanoma cells or LPS

hematopoietic system
• CD8+ T cell numbers are increased following exposure to two B16-F10-specific epitopes or mouse lymphoma cell line EL4

homeostasis/metabolism
• IL-12 levels are increased following treatment with LPs or LPS and interferon-gamma
• IL-10 levels are decreased following treatment with melanoma cells or LPS


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory