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Phenotypes Associated with This Genotype
Genotype
MGI:3713871
Allelic
Composition		 Smad4m4Mag/Smad4tm1Cxd
Genetic
Background		 either: (involves: 129S/Sv * 129S6/SvEvTac * Black Swiss) or (involves: 129S/Sv * 129S6/SvEvTac * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad4m4Mag mutation (0 available); any Smad4 mutation (43 available)
Smad4tm1Cxd mutation (0 available); any Smad4 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:80520 )
• embryos do not survive embryogenesis, and display defects not compatible with life aound ~E7.5

embryo
embryonic growth retardation ( J:80520 )
• at E7.5, animals are severely growth retarded
absent mesoderm ( J:80520 )
• embryos do not form mesoderm due to failure of gastrulation

growth/size/body
embryonic growth retardation ( J:80520 )
• at E7.5, animals are severely growth retarded

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory