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Phenotypes Associated with This Genotype
Genotype
MGI:3713741
Allelic
Composition
Scn1atm1Kzy/Scn1atm1Kzy
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn1atm1Kzy mutation (0 available); any Scn1a mutation (49 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean life time is 15.8+/-0.8 days regardless of weight

behavior/neurological
• between P12 and P16
• between P12 and P16
• at P10, mice have abnormal and unstable gait
• recurrent seizures develop at P12
• between P12 and P16, seizures last 1 to 3 minutes and occur at intervals of about 1 to 4 hours
• however, genetic background percentage has little effect on seizure occurrences
• between P12 and P16
• between P12 and P16

growth/size/body
• between P14 and P15 there is a 40% reduction in body weight compared with controls
• due to malnutrition from P10

nervous system
• recurrent seizures develop at P12
• between P12 and P16, seizures last 1 to 3 minutes and occur at intervals of about 1 to 4 hours
• however, genetic background percentage has little effect on seizure occurrences
• between P12 and P16
• between P12 and P16

Mouse Models of Human Disease
OMIM ID Ref(s)
Epileptic Encephalopathy, Early Infantile, 6; EIEE6 607208 J:121969


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory