Mouse Genome Informatics
hm
    Scn1atm1Kzy/Scn1atm1Kzy
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• mean life time is 15.8+/-0.8 days regardless of weight

behavior/neurological
• between P12 and P16
• between P12 and P16
• at P10, mice have abnormal and unstable gait
• recurrent seizures develop at P12
• between P12 and P16, seizures last 1 to 3 minutes and occur at intervals of about 1 to 4 hours
• however, genetic background percentage has little effect on seizure occurrences
• between P12 and P16
• between P12 and P16

growth/size
• between P14 and P15 there is a 40% reduction in body weight compared with controls
• due to malnutrition from P10

nervous system
• recurrent seizures develop at P12
• between P12 and P16, seizures last 1 to 3 minutes and occur at intervals of about 1 to 4 hours
• however, genetic background percentage has little effect on seizure occurrences
• between P12 and P16
• between P12 and P16

Mouse Models of Human Disease
OMIM IDRef(s)
Dravet Syndrome 607208 J:121969