Mouse Genome Informatics
ht
    Gcktm2Mgn/Gck+
129S6/SvEvTac-Gcktm2Mgn
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• ratio between plasma insulin and blood glucose level is significantly higher throughout the 120-minute period after glucose challenge
• mice are less sensitive to glucose and islets secret insulin in response to 8.0mM glucose
• fasted 4-week old mice display mild hyperglycemia
• glucose regulation is impaired in mice
• glucokinase activity is reduced ~43% compared to wild-type mice

endocrine/exocrine glands
N
• islets have similar morphology and total insulin content to wild-type islets when mice are fed a normal diet (J:121910)
• mice are less sensitive to glucose and islets secret insulin in response to 8.0mM glucose

Mouse Models of Human Disease
OMIM IDRef(s)
Maturity-Onset Diabetes of the Young, Type 2; MODY2 125851 J:121910