Phenotypes Associated with This Genotype

Genotype
MGI:3713129

• Allelic Composition: Akap10^{Gt(RRC139)Byg}/Akap10^{Gt(RRC139)Byg}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:121838 )

• Background Sensitivity: on a 129P2/OlaHsd background, 50% of mice die within 1 year; mortality is observed only in adult animals

cardiovascular system

abnormal sinus arrhythmia ( J:121838 )

• at greater than 10 weeks of age, unstressed mice show pronounced sinus arrhythmia

increased heart rate variability ( J:121838 )

• unstressed mice older than 10 weeks have abnormally high beat-to-beat heart rate variability (HRV)

decreased heart rate ( J:121838 )

• treatment of mice with cholinergic agonists results in greater slowing of heart rate compared to wild-type at more than 10 weeks of age

irregular heartbeat ( J:121838 )

atrioventricular block ( J:121838 )

abnormal sinoatrial node conduction ( J:121838 )

• mice show sinus pauses with junctional escape beats at a 40-fold increased frequency compared to wild-type (preceded by sinus slowing with prolonged P-P wave interval)

abnormal P wave ( J:121838 )

• mutants exhibit 3 vs 0.2 in wild-type nonconductive P waves/hour (AV heartblock)

nervous system

abnormal baroreceptor physiology ( J:121838 )

• mice display stronger baroreflexes upon activation of vagus nerve with phenylephrine