About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3713124
Allelic
Composition
EdaTa-6J/Y
Tg(MMTVtTA)1Mam/0
Tg(tetO-Eda*A1)1Dsch/0
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
EdaTa-6J mutation (5 available); any Eda mutation (34 available)
Tg(MMTVtTA)1Mam mutation (3 available)
Tg(tetO-Eda*A1)1Dsch mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• at 5 months of age, weight is about 80% of wild-type in the absence of doxicycline

endocrine/exocrine glands
• in the presence of doxicycline throughout embryonic development to suppress Eda-A1 transgene expression, males are identical to EdaTa-6J males, showing lack of sweat glands; mice continue to show this phenotype even after withdrawal of doxicycline from the food at 6 months of age
• preputial gland is not restored by transgene expression
• in the absence of doxicycline, sebaceous glands are enlarged relative to wild-type or EdaTa-6J males; size of individual sebocytes is the same but the numbers are increased, with excessive production of sebum
• meibomian glands are not restored by transgene expression (J:86628)
• however, Eda transgene expression does restore the sweat glands that are absent in EdaTa-6J males (J:86628)
(J:99510)
• in the absence of doxicycline, sebaceous glands are 200-300% larger than in wild-type or EdaTa-6J males; size of individual sebocytes is the same but the numbers are increased
• hyperplasia is seen in both glands associated with each de novo guard follicle and also in the single sebaceous gland associated with each medium follicle
• addition of doxicycline at 3 months of age reverses the hyperplasia of sebaceous glands within 3 months
• transgene expression results in hypertrophy of sebaceous glands associated with hair follicles of the eyelids
• in the absence of doxicycline

vision/eye
• meibomian glands are not restored by transgene expression (J:86628)
• however, Eda transgene expression does restore the sweat glands that are absent in EdaTa-6J males (J:86628)
(J:99510)

immune system
N
• transgene expression rescues the susceptibility to corneal inflammation seen in EdaTa-6J males

reproductive system
• preputial gland is not restored by transgene expression

renal/urinary system
• preputial gland is not restored by transgene expression

integument
• preputial gland is not restored by transgene expression
• in the absence of doxicycline, sebaceous glands are enlarged relative to wild-type or EdaTa-6J males; size of individual sebocytes is the same but the numbers are increased, with excessive production of sebum
• in the absence of doxicycline, sebaceous glands are 200-300% larger than in wild-type or EdaTa-6J males; size of individual sebocytes is the same but the numbers are increased
• hyperplasia is seen in both glands associated with each de novo guard follicle and also in the single sebaceous gland associated with each medium follicle
• addition of doxicycline at 3 months of age reverses the hyperplasia of sebaceous glands within 3 months
• transgene expression results in hypertrophy of sebaceous glands associated with hair follicles of the eyelids
• in the absence of doxicycline
• in the absence of doxicycline, the number of medium hairs is increased to a similar extent as in EdaTa-6J males
• however, total hair numbers are unchanged
• in the presence of doxicycline throughout embryonic development to suppress Eda-A1 transgene expression, males are identical to EdaTa-6J males, showing lack of tail hair, guard hair and zigzag hair; mice continue to show this phenotype even after withdrawal of doxicycline from the food at 6 months of age
• in the absence of doxicycline, tail hairs are reduced in number
• however, the hair behind the ears that is missing in EdaTa-6J males is fully restored when the transgene is expressed (absence of doxicycline)
• in the absence of doxicycline, tail hairs are reduced in length
• in the absence of doxicycline, mutants have somewhat scruffy disordered coat hair compared to wild-type and EdaTa-6J males
• zigzag hairs are not restored by transgene expression (absence of doxicycline)
• however, the number of guard hairs is restored to wild-type levels
• tail ridges on skin surfaces are absent in the absence of doxicycline
• meibomian glands are not restored by transgene expression (J:86628)
• however, Eda transgene expression does restore the sweat glands that are absent in EdaTa-6J males (J:86628)
(J:99510)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory