Phenotypes Associated with This Genotype

Genotype
MGI:3712799

• Allelic Composition: Gjb3^tm2.1Kwi/Gjb3⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

enhanced wound healing ( J:121802 )

• tail incision wounds close 1 day earlier than in wild-type

• fusion of the epidermis in mutated animals results in distinct stratification at day 3 of healing process, while this stage in not reached until day 4 in wild-type mice

integument

epidermal hyperplasia ( J:121802 )

• hyperproliferation of keratinocytes is seen in ~5% of tail skin but never in wild-type tail skin

thick epidermis ( J:121802 )

• thickening of the epidermis at site of wound healing is observed

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
erythrokeratodermia variabilis		DOID:0050467	OMIM:PS133200	J:121802