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Phenotypes Associated with This Genotype
Genotype
MGI:3712799
Allelic
Composition
Gjb3tm2.1Kwi/Gjb3+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gjb3tm2.1Kwi mutation (1 available); any Gjb3 mutation (97 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• tail incision wounds close 1 day earlier than in wild-type
• fusion of the epidermis in mutated animals results in distinct stratification at day 3 of healing process, while this stage in not reached until day 4 in wild-type mice

integument
• hyperproliferation of keratinocytes is seen in ~5% of tail skin but never in wild-type tail skin
• thickening of the epidermis at site of wound healing is observed

Mouse Models of Human Disease
OMIM ID Ref(s)
Erythrokeratodermia Variabilis Et Progressiva; EKVP 133200 J:121802


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory