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Phenotypes Associated with This Genotype
Genotype
MGI:3712469
Allelic
Composition		 Thbdtm2Emc/Thbdtm2Emc
Genetic
Background		 either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thbdtm2Emc mutation (0 available); any Thbd mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to induced morbidity/mortality ( J:118000 )
• during hypoxia 7 of 18 mice die with diffuse lung fibrin depositions compared to only one wild-type mouse

immune system
abnormal leukocyte physiology ( J:118000 )
• leukocyte accumulation in the lung is increased

hematopoietic system
abnormal leukocyte physiology ( J:118000 )
• leukocyte accumulation in the lung is increased

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
thrombophilia DOID:2452 OMIM:PS188050
 J:118000

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory