Phenotypes Associated with This Genotype

Genotype
MGI:3712287

• Allelic Composition: Mecp2^tm2Bird/Mecp2⁺; Tg(CAG-cre/Esr1*)5Amc/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:118365 )

♀ • at 4 to 12 months of age, mice exhibit a progressive development of RTT-like symptoms (inertia, gait, hindlimb clasping, tremor, irregular breathing and poor general condition)

♀ • however, tamoxifen treatment after the onset of symptoms reverses symptom progression

limb grasping ( J:118365 )

♀ • at 4 to 12 months of age

♀ • however, tamoxifen treatment after the onset of symptoms reverses symptom progression

tremors ( J:118365 )

♀ • at 4 to 12 months of age

♀ • however, tamoxifen treatment after the onset of symptoms reverses symptom progression

nervous system

reduced long-term potentiation ( J:118365 )

♀ • mice develop a reduction in long term potentiation

♀ • however, treatment with tamoxifen returns long term potentiation to normal levels

respiratory system

abnormal breathing pattern ( J:118365 )

♀ • at 4 to 12 months of age

♀ • however, tamoxifen treatment after the onset of symptoms reverses symptom progression

growth/size/body

obese ( J:118365 )

♀ • mice exhibit excess weight gain

♀ • however, tamoxifen treatment after the onset of symptoms reverses weight gain