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Phenotypes Associated with This Genotype
Genotype
MGI:3711994
Allelic
Composition		 Krt8tm1Rgo/Krt8tm1Rgo
Tnftm1Gkl/Tnftm1Gkl
Genetic
Background		 involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt8tm1Rgo mutation (1 available); any Krt8 mutation (34 available)
Tnftm1Gkl mutation (6 available); any Tnf mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:121811 )
N
• about 60% survive beyond 250 days
prenatal lethality, incomplete penetrance ( J:121811 )
• Background Sensitivity: about 50% survive to birth as opposed to 25% when maternal TNF is produced

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory