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Phenotypes Associated with This Genotype
Genotype
MGI:3711774
Allelic
Composition
Mir208atm1.1Eno/Mir208atm1.1Eno
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir208atm1.1Eno mutation (0 available); any Mir208a mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• in response to thoracic aortic banding (TAB), mutant animals show almost no cardiomyocyte hypertrophy or fibrosis
• left ventricular diameter increases during systole
• in mice >6 months of age, cardiac function declines
• in response to TAB, null animals display a blunted hypertrophic response
• slight reduction in contractility compared to wild-type at 2 months of age
• in response to thoracic aortic banding (TAB), contractility is reduced

muscle
• in response to thoracic aortic banding (TAB), mutant animals show almost no cardiomyocyte hypertrophy or fibrosis
• slight reduction in contractility compared to wild-type at 2 months of age
• in response to thoracic aortic banding (TAB), contractility is reduced
• in mice >6 months of age, abnormalities in sarcomere structure are observed


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory