Phenotypes Associated with This Genotype

Genotype
MGI:3711763

• Allelic Composition: Cks1b^tm1Sir/Cks1b^tm1Sir; Tg(IghMyc)22Bri/?
• Genetic Background: involves: C57BL * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:121564 )

• mean survival after lymphomas develop is 268 days compared to 91 days in Tg(IghMyc)22Bri mice and 101 days in Tg(IghMyc)22Bri Cks1b^tm1Sir heterozygotes

neoplasm

decreased metastatic potential ( J:121564 )

• only 1 of 9 diseased mice show moderate bone marrow infiltration and none presented with liver or meningeal infiltrates present in Tg(IghMyc)22Bri mice

increased lymphoma incidence ( J:121564 )

• delayed development of lymphomas compared to Tg(IghMyc)22Bri mice

immune system

decreased B cell proliferation ( J:121564 )

• severely impaired proliferative response compared to Tg(IghMyc)22Bri mice

decreased leukocyte cell number ( J:121564 )

decreased lymphocyte cell number ( J:121564 )

• 5.4+/-0.4x10⁶ul compared to 6.9+/-0.4x10⁶ul in Tg(IghMyc)22Bri mice

decreased spleen weight ( J:121564 )

• at 4 weeks, mice have significantly smaller spleens than Tg(IghMyc)22Bri counter parts (83+/-11mg compared to 157+/-7mg)

hematopoietic system

decreased B cell proliferation ( J:121564 )

• severely impaired proliferative response compared to Tg(IghMyc)22Bri mice

decreased leukocyte cell number ( J:121564 )

decreased lymphocyte cell number ( J:121564 )

• 5.4+/-0.4x10⁶ul compared to 6.9+/-0.4x10⁶ul in Tg(IghMyc)22Bri mice

decreased spleen weight ( J:121564 )

• at 4 weeks, mice have significantly smaller spleens than Tg(IghMyc)22Bri counter parts (83+/-11mg compared to 157+/-7mg)

cellular

decreased B cell proliferation ( J:121564 )

• severely impaired proliferative response compared to Tg(IghMyc)22Bri mice