Phenotypes Associated with This Genotype

Genotype
MGI:3711322

• Allelic Composition: Ghrl^tm1Mko/Ghrl^tm1Mko
• Genetic Background: B6.Cg-Ghrl^tm1Mko

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:121019 )

N • no differences in size or density of pancreatic islets are seen compared to wild-type

increased insulin secretion ( J:121019 )

• glucose-induced insulin release is significantly higher than in wild-type mice, while basal insulin release levels are not different from wild-type; amount released/islet is increased in response to glucose compared to wild-type

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:121019 )

N • 8-week old mice fed regular chow show no differences in body weight, total 24-hour food intake, and serum glucose levels relative to controls

abnormal glucose homeostasis ( J:121019 )

• responses to insulin tolerance tests are not different from wild-type, indicating no differences in insulin sensitivity

increased insulin secretion ( J:121019 )

• glucose-induced insulin release is significantly higher than in wild-type mice, while basal insulin release levels are not different from wild-type; amount released/islet is increased in response to glucose compared to wild-type

decreased circulating glucose level ( J:121019 )

• in glucose tolerance tests, mice show attenuated elevation of blood glucose levels relative to wild-type

• on a high-fat diet, glucose levels do not increase as much as in wild-type in glucose tolerance tests; at 15-20 minutes after injection, levels are similar to control diet group

• when fed a high-fat diet, mice do not show the same moderate increase in glucose level as wild-type mice

increased circulating insulin level ( J:121019 )

• in glucose tolerance tests, mice show attenuated elevation of insulin levels relative to wild-type

• on a high-fat diet, increases in insulin levels are much greater than in wild-type mice; in a glucose tolerance test, insulin levels at 15 minutes are markedly enhancec compared to wild-type

improved glucose tolerance ( J:121019 )

• mice are resistant to glucose intolerance on a high-fat diet