Analysis Tools
nervous system
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• cultured medium spiny neurons are resistant to NMDAR-mediated excitotoxicity compared to wild-type (2.4% apoptotic cells vs 8.6% in wild-type cultures)
• in vivo, quinolinic acid-induced lesion volume is less than that observed in wild-type mice
• medium spiny neurons exposed to staurosporine show less cell death than wild-type neurons in culture (20% apoptotic cells vs 36.8% in wild-type cultures)
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homeostasis/metabolism
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• cultured medium spiny neurons are resistant to NMDAR-mediated excitotoxicity compared to wild-type (2.4% apoptotic cells vs 8.6% in wild-type cultures)
• in vivo, quinolinic acid-induced lesion volume is less than that observed in wild-type mice
• medium spiny neurons exposed to staurosporine show less cell death than wild-type neurons in culture (20% apoptotic cells vs 36.8% in wild-type cultures)
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cellular
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• cultured medium spiny neurons are resistant to NMDAR-mediated excitotoxicity compared to wild-type (2.4% apoptotic cells vs 8.6% in wild-type cultures)
• in vivo, quinolinic acid-induced lesion volume is less than that observed in wild-type mice
• medium spiny neurons exposed to staurosporine show less cell death than wild-type neurons in culture (20% apoptotic cells vs 36.8% in wild-type cultures)
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