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Phenotypes Associated with This Genotype
Genotype
MGI:3711004
Allelic
Composition
Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc
Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3(SS18/EGFP)Mrc mutation (0 available); any Gt(ROSA)26Sor mutation (305 available)
Myf5tm1(cre)Mrc mutation (1 available); any Myf5 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• about 8% of mice die by 2 months of age (J:120967)
• about 8% of mice die by 2 months of age (J:120967)

tumorigenesis
• at 3 to 5 months, 18 of 18 surviving mice developed multiple tumors (3 to 5 per mouse) compared to over 100 control mice who did not develop tumors at more than 1 year of age (J:120967)
• however, mice that died prior to 2 months of age did not have tumors and did not die from tumor-related causes (J:120967)
• small and potentially metastatic tumors are detected (J:120967)
• most tumors are located within the skeletal muscle in the limbs and intercostals regions with some non-skeletal muscle tissues (such as the cerebellum) harboring tumors (J:120967)
• tumors are vascularized, hemorrhagic and cystic spaces are detected in large tumors (J:120967)
• at 3 to 5 months, 18 of 18 surviving mice developed multiple tumors (3 to 5 per mouse) compared to over 100 control mice who did not develop tumors at more than 1 year of age (J:120967)
• however, mice that died prior to 2 months of age did not have tumors and did not die from tumor-related causes (J:120967)
• small and potentially metastatic tumors are detected (J:120967)
• most tumors are located within the skeletal muscle in the limbs and intercostals regions with some non-skeletal muscle tissues (such as the cerebellum) harboring tumors (J:120967)
• tumors are vascularized, hemorrhagic and cystic spaces are detected in large tumors (J:120967)
• synovial sarcomas are detected with monophasic (13) outnumbering biphasic (3) (J:120967)
• myxoid and fibrous changes are observed (J:120967)
• synovial sarcomas are detected with monophasic (13) outnumbering biphasic (3) (J:120967)
• myxoid and fibrous changes are observed (J:120967)

muscle
• myf5+ lineage cells undergo increased apoptosis ate E11.5 and by E15.5 are absent (J:120967)
• however, myf5+ cells near future rib cartilage and skeletal musculogenesis are normal (J:120967)
• myf5+ lineage cells undergo increased apoptosis ate E11.5 and by E15.5 are absent (J:120967)
• however, myf5+ cells near future rib cartilage and skeletal musculogenesis are normal (J:120967)

growth/size/body
• about 8% of mice are born small (J:120967)
• about 8% of mice are born small (J:120967)

Mouse Models of Human Disease
OMIM ID Ref(s)
Sarcoma, Synovial 300813 J:120967


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory