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Phenotypes Associated with This Genotype
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3(SS18/EGFP)Mrc mutation (0 available); any Gt(ROSA)26Sor mutation (291 available)
Myf5tm1(cre)Mrc mutation (1 available); any Myf5 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• about 8% of mice die by 2 months of age

• at 3 to 5 months, 18 of 18 surviving mice developed multiple tumors (3 to 5 per mouse) compared to over 100 control mice who did not develop tumors at more than 1 year of age
• however, mice that died prior to 2 months of age did not have tumors and did not die from tumor-related causes
• small and potentially metastatic tumors are detected
• most tumors are located within the skeletal muscle in the limbs and intercostals regions with some non-skeletal muscle tissues (such as the cerebellum) harboring tumors
• tumors are vascularized, hemorrhagic and cystic spaces are detected in large tumors
• synovial sarcomas are detected with monophasic (13) outnumbering biphasic (3)
• myxoid and fibrous changes are observed

• myf5+ lineage cells undergo increased apoptosis ate E11.5 and by E15.5 are absent
• however, myf5+ cells near future rib cartilage and skeletal musculogenesis are normal

• about 8% of mice are born small

Mouse Models of Human Disease
OMIM ID Ref(s)
Sarcoma, Synovial 300813 J:120967

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory