Mouse Genome Informatics
hm
    Fkbp4tm1Shou/Fkbp4tm1Shou
involves: 129S/SvEv
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Abnormal male reproductive anatomy in Fkbp4tm1Shou/Fkbp4tm1Shou mice

reproductive system
• shortened in mice 3 to 10 weeks of age
• feminization phenotype, similar to that seen in androgen receptor null mice, occurs less frequently (J:120960)
• however, primary sex organs (testes, epididymis, scrotal sac and inguinal canals) are normal (J:120960)
• prostate glands initially form but lack further growth at puberty and become dysgenic (J:120960)
• 5.28+/-1.58mg/g compared to 7.40+/-1.31mg/g in wild-type (J:120960)
• ectopic opening on the ventral side of the penis (J:120960)
• foreskin is underdeveloped exposing the penile glans and anterior portion of the tubercle (J:120960)
• penile length (44.4+/-0.33mm compared to 6.1+/-0.16mm in wild-type) and weight (0.56+/-0.16mg/g compared to 0.77+/-0.13mg/g in wild-type) are decreased (J:120960)
• females are infertile due to implantation failure (J:120960)
• males mated to wild-type females yield smaller litters (2.1+/-0.9 pups) compared to wild-type (6.8+/-1.6 pups)
• male mice have greatly reduced fertility with only 5% of mice being able to plug females (J:120960)
• slightly reduced (47.7+/-8.8 compared to 69.0+/-8.8 in wild-type) (J:120960)

homeostasis/metabolism
• slightly increased serum testosterone and DHT levels

growth/size
• males weigh less postnatally
• males exhibit decreased growth rates compared to females and wild-type mice

renal/urinary system
• ectopic opening on the ventral side of the penis (J:120960)
• foreskin is underdeveloped exposing the penile glans and anterior portion of the tubercle (J:120960)
• penile length (44.4+/-0.33mm compared to 6.1+/-0.16mm in wild-type) and weight (0.56+/-0.16mg/g compared to 0.77+/-0.13mg/g in wild-type) are decreased (J:120960)
• found in 100% of the external penile genitalia
• developmental defect resulting from the failure to form urethral seams

digestive/alimentary system
• shortened in mice 3 to 10 weeks of age

endocrine/exocrine glands
• prostate glands initially form but lack further growth at puberty and become dysgenic (J:120960)
• 5.28+/-1.58mg/g compared to 7.40+/-1.31mg/g in wild-type (J:120960)

Mouse Models of Human Disease
OMIM IDRef(s)
Androgen Insensitivity Syndrome; AIS 300068 J:120960