Phenotypes for Taf7l MGI:3710418 MGI Mouse

asthenozoospermia ( J:121371 )

• sperm motility is further reduced from 56.3% to 45.5% upon capacitation

• percentage of motile sperm is reduced (56.3+/-2.1% compared to 72.7+/-4.2% in wild-type), all three velocity parameters are significantly lower, and while sperm beat more rapidly they fail to produce motion

abnormal testis morphology ( J:121371 )

abnormal seminiferous tubule morphology ( J:121371 )

• in testes of mice older than 7 months, at least one large vacuole develops in 15.2+/-4.6% of tubules

decreased testis weight ( J:121371 )

• at 8 weeks, testes weigh 10% less than in wild-type mice

abnormal gametogenesis ( J:121371 )

oligozoospermia ( J:121371 )

• sperm counts are reduced by greater than 50%

teratozoospermia ( J:121371 )

• at 8 weeks, 46% of sperm tails are folded or angulated compared to 5.8% in wild-type

• cytoplasmic membrane is retracted from the region of folding

hairpin sperm flagellum ( J:121371 )

• sperm tails are frequently bent by 180 within the middle piece or at the junction between the middle and principal pieces

kinked sperm flagellum ( J:121371 )

• sharp angulation of sperm tails at the junction of the middle and principal pieces is frequently observed

decreased litter size ( J:121371 )

• Background Sensitivity: unlike mice on a mixed background, males congenic on a 129 background produce smaller litter sizes of 3.8+/-2.1 pups compared to 8.3+/-2.5 pups in wild-type

reduced male fertility ( J:121371 )