Phenotypes Associated with This Genotype

Genotype
MGI:3709595

• Allelic Composition: Cebpa^tm5Nerl/Cebpa^tm5Nerl
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

liver/biliary system phenotype ( J:120098 )

N • hepatocyte proliferation is not increased compared to wild-type

increased liver triglyceride level ( J:120098 )

• hepatic triglyceride content is significantly increased in fed mice

abnormal hepatocyte morphology ( J:120098 )

• primary hepatocytes display increase in lipid content similar to that observed in vivo when cells are cultured under serum free conditions

abnormal liver physiology ( J:120098 )

• four biosynthetic enzymes show downregulation of mRNA expression in mutants; the mRNAs for ATP citrate lyase (ACL), malic enzyme (ME), acetyl-CoA synthase 2 (ACAS2) and glutamate-oxaloacetate transaminase 1 (GOT1) are reduced in mutants relative to wild type

• metabolic regulation of ACL and ACAS2 is severely compromised in mutants upon fasting, while regulation of ME is inverted (upregulation) with respect to wild-type in which these enzymes are downregulated

homeostasis/metabolism

increased liver triglyceride level ( J:120098 )

• hepatic triglyceride content is significantly increased in fed mice

adipose tissue

adipose tissue phenotype ( J:120098 )

N • no differences in amount or appearance of white adipose tissue is seen relative to wild-type