About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3709041
Allelic
Composition
Myo7apolka/Myo7apolka
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo7apolka mutation (0 available); any Myo7a mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• low auditory startle response (J:119820)
• low auditory startle response (J:119820)
• disoriented (J:119820)
• disoriented (J:119820)

hearing/vestibular/ear
• stereociliary bundles are disorganized in all four rows of hair cells of the cochlear sensory epithelium (J:157102)
• often lacking clear polarity (J:157102)
• stereociliary bundles are disorganized in all four rows of hair cells of the cochlear sensory epithelium (J:157102)
• often lacking clear polarity (J:157102)
• stereocilia are often short (J:157102)
• stereocilia are often short (J:157102)
• auditory threshold of more than 90 dB, indicating that lines are severely hearing impaired in 8- to 12 week old animals (J:119820)
• auditory threshold of more than 90 dB, indicating that lines are severely hearing impaired in 8- to 12 week old animals (J:119820)
• not detectable (J:157102)
• not detectable (J:157102)

vision/eye
• melanosomes fail to localize to the apical processes of retinal pigment cells (J:157102)
• melanosomes fail to localize to the apical processes of retinal pigment cells (J:157102)

nervous system
• stereociliary bundles are disorganized in all four rows of hair cells of the cochlear sensory epithelium (J:157102)
• often lacking clear polarity (J:157102)
• stereociliary bundles are disorganized in all four rows of hair cells of the cochlear sensory epithelium (J:157102)
• often lacking clear polarity (J:157102)
• stereocilia are often short (J:157102)
• stereocilia are often short (J:157102)

pigmentation
• melanosomes fail to localize to the apical processes of retinal pigment cells (J:157102)
• melanosomes fail to localize to the apical processes of retinal pigment cells (J:157102)

Mouse Models of Human Disease
OMIM ID Ref(s)
Usher Syndrome, Type I; USH1 276900 J:157102


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory