Mouse Genome Informatics
hm
    Chd7Gt(S20-7E1)Sor/Chd7Gt(S20-7E1)Sor
involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Abnormal development in Chd7Gt(S20-7E1)Sor/Chd7Gt(S20-7E1)Sor mice and delayed turning in Chd7Gt(S20-7E1)Sor/Chd7+ embryos

mortality/aging
• no embryos are found after E10.5

hearing/vestibular/ear
• at E10.5, the otocyst is thickened
• at E10.5

embryogenesis
• reduced thickness of the neuroepithelium in the telencephalon, midbrain, and spinal cord

endocrine/exocrine glands

respiratory system
• hypoplasia of the olfactory pits at E10.5

vision/eye
• hypoplasia of the optic eminence at E10.5

limbs/digits/tail
• hypoplasia of the hindlimbs at E10.5

nervous system
• reduced thickness of the neuroepithelium in the telencephalon, midbrain, and spinal cord
• hypoplastic trigeminal ganglion

craniofacial
• hypoplasia of the olfactory pits at E10.5

Mouse Models of Human Disease
OMIM IDRef(s)
CHARGE Syndrome 214800 J:119812