Phenotypes Associated with This Genotype

Genotype
MGI:3707354

• Allelic Composition: Gins1^tm1Ntak/Gins1^tm1Ntak
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:119867 )

• embryos fail to develop past E5.5

embryo

abnormal inner cell mass apoptosis ( J:119867 )

• apoptotic cells appear in ICM of mutant blastocyst cultures on day 5, while heterozygous blastocysts continuously proliferate after 10 days of culture

absent inner cell mass proliferation ( J:119867 )

• in culture, trophoblasts attach to the dish, but ICM cells fail to form outgrowths

• ICM cells stop proliferating, while trophoblast cells continue to proliferate

embryonic growth arrest ( J:119867 )

• embryos fail to develop past E5.5; at E6.5, wild-type embryos have a cylinder-like 2-layered structure, but homozygotes lack this structure

disorganized embryonic tissue ( J:119867 )

• at E6.5, homozygotes display disorganized embryonic structures

disorganized extraembryonic tissue ( J:119867 )

• at E6.5, homozygotes display disorganized extraembryonic structures

cellular

abnormal inner cell mass apoptosis ( J:119867 )

• apoptotic cells appear in ICM of mutant blastocyst cultures on day 5, while heterozygous blastocysts continuously proliferate after 10 days of culture

absent inner cell mass proliferation ( J:119867 )

• in culture, trophoblasts attach to the dish, but ICM cells fail to form outgrowths

• ICM cells stop proliferating, while trophoblast cells continue to proliferate