Phenotypes Associated with This Genotype

Genotype
MGI:3707262

• Allelic Composition: Nckap1^Gt(XE068)Byg/Nckap1^Gt(XE068)Byg
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:119028 )

• phenotype is stated to be similar to that of Nckap1^khlo homozygotes; however very little data is presented in J:119028

embryo

abnormal developmental patterning ( J:119028 )

rostral-caudal axis duplication ( J:119028 )

• primitive streak-derived structures, including the node and the notochord are duplicated in 8% of embryos at E8.5

embryonic growth arrest ( J:119028 )

• embryos arrest at E9

abnormal neural tube morphology ( J:119028 )

abnormal somite development ( J:119028 )

abnormal allantois morphology ( J:119028 )

• in 4 out of 7 embryos, only the allantois is duplicated

cardiovascular system

abnormal heart development ( J:119028 )

digestive/alimentary system

abnormal digestive system development ( J:119028 )

nervous system

abnormal neural tube morphology ( J:119028 )