Phenotypes for Tlr2 Tlr4 MGI:3706993 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Tlr2^tm1Kir/Tlr2^tm1Kir Tlr4^tm1Aki/Tlr4^tm1Aki
Genetic Background	B6.129-Tlr2^tm1Kir Tlr4^tm1Aki

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr2^tm1Kir mutation (2 available); any Tlr2 mutation (56 available)
Tlr4^tm1Aki mutation (7 available); any Tlr4 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:121930 )

• systemic challenge with Myr3-CSK4 after D-galactosamine induces lethal shock in wild-type mice, but mutants are protected

• mice are resistant to lethal toxemia induced by heat-inactivated E. coli, whereas wild-type mice die

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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