Phenotypes Associated with This Genotype

Genotype
MGI:3706959

• Allelic Composition: Wwox^tm1Ria/Wwox^tm1Ria
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Tumor phenotype in Wwox^tm1Ria/Wwox^tm1Ria mice

mortality/aging

premature death ( J:120064 )

• mice die by 4 weeks of age

neoplasm

increased osteosarcoma incidence ( J:120064 )

• 4 of 13 mice examined had focal lesions along with dysplasia that appeared neoplastic, one each at age day 3 and 5 and 2 mice at age 2.5 week

• tumor motphology suggests these are either periosteal or chondroid osteosarcomas

• lesions contain enlarged cells in the cartilage matrix with multiple nucleoli

skeleton

increased osteosarcoma incidence ( J:120064 )

• 4 of 13 mice examined had focal lesions along with dysplasia that appeared neoplastic, one each at age day 3 and 5 and 2 mice at age 2.5 week

• tumor motphology suggests these are either periosteal or chondroid osteosarcomas

• lesions contain enlarged cells in the cartilage matrix with multiple nucleoli