Phenotypes Associated with This Genotype

Genotype
MGI:3706828

• Allelic Composition: Foxo3^tm1.1Rdp/Foxo3⁺; Foxo4^tm1.1Rdp/Foxo4^tm1.1Rdp
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:118179 )

♀ • other unclassified tumors are seen with higher frequencies (1/9 vs 0 wild-type)

increased Harderian gland tumor incidence ( J:118179 )

♀ • mice show increased incidence of Harderian gland tumors (2/9 vs 1/6 wild-type)

increased ovary tumor incidence ( J:118179 )

♀ • slightly increased incidence of ovarian stromal neoplasms in females (1/5 vs 0 wild-type)

increased pituitary adenoma incidence ( J:118179 )

♀ • females show increased pituitary adenoma (1/5 vs 0 wild-type)

reproductive system

increased ovary tumor incidence ( J:118179 )

♀ • slightly increased incidence of ovarian stromal neoplasms in females (1/5 vs 0 wild-type)

endocrine/exocrine glands

increased Harderian gland tumor incidence ( J:118179 )

♀ • mice show increased incidence of Harderian gland tumors (2/9 vs 1/6 wild-type)

increased ovary tumor incidence ( J:118179 )

♀ • slightly increased incidence of ovarian stromal neoplasms in females (1/5 vs 0 wild-type)

increased pituitary adenoma incidence ( J:118179 )

♀ • females show increased pituitary adenoma (1/5 vs 0 wild-type)

nervous system

increased pituitary adenoma incidence ( J:118179 )

♀ • females show increased pituitary adenoma (1/5 vs 0 wild-type)