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Phenotypes Associated with This Genotype
Genotype
MGI:3706828
Allelic
Composition
Foxo3tm1.1Rdp/Foxo3+
Foxo4tm1.1Rdp/Foxo4tm1.1Rdp
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo3tm1.1Rdp mutation (1 available); any Foxo3 mutation (11 available)
Foxo4tm1.1Rdp mutation (0 available); any Foxo4 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• slightly increased incidence of ovarian stromal neoplasms in females (1/5 vs 0 wild-type)

endocrine/exocrine glands
• mice show increased incidence of Harderian gland tumors (2/9 vs 1/6 wild-type)
• slightly increased incidence of ovarian stromal neoplasms in females (1/5 vs 0 wild-type)
• females show increased pituitary adenoma (1/5 vs 0 wild-type)

nervous system
• females show increased pituitary adenoma (1/5 vs 0 wild-type)

neoplasm
• other unclassified tumors are seen with higher frequencies (1/9 vs 0 wild-type)
• mice show increased incidence of Harderian gland tumors (2/9 vs 1/6 wild-type)
• slightly increased incidence of ovarian stromal neoplasms in females (1/5 vs 0 wild-type)
• females show increased pituitary adenoma (1/5 vs 0 wild-type)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory