Mouse Genome Informatics
hm
    Nebtm1Slbt/Nebtm1Slbt
involves: 129P2/OlaHsd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• the remaining 10% of animals die during their third week
• about 90% die within the first 2 weeks after birth

growth/size/body
• already growth-retarded at day 1 after birth and over the full postnatal range that was tested

behavior/neurological
• develop a stiff gait

skeleton

vision/eye
• severe muscle weakness as indicated by ptosis

muscle
• the absence of H-zones
• shorter thin filaments
• maximal active tension of skinned muscle fibers is significantly reduced
• between day 10 and 20
• indicated by their inability to climb, hold their weight when clinging to a spatula, and inability to keep their eyes open
• able to walk up to week 3

Mouse Models of Human Disease
OMIM IDRef(s)
Nemaline Myopathy 2; NEM2 256030 J:149329