Mouse Genome Informatics
cx
    Agertm1.1Hyam/Agertm1.1Hyam
Tg(Ins2-Nos2)40Okam/0

involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• serum creatinine is much lower than in Ager-sufficient transgenic mice at 8 months
• mice show sustained hyperglycemia (and display diabetes)
• urinary albumin/creatinine ratio is much lower than in wild-type transgenic mice or nontransgenic controls at 4 and 8 months

renal/urinary system
• urinary albumin/creatinine ratio is much lower than in wild-type transgenic mice or nontransgenic controls at 4 and 8 months
• progression of sclerosis is attenuated in mice compared to Ager-sufficient transgenic mice
• kidney weight as percentage of body weight is attenuated with Ager-deficiency; kidney weight as percentage of body weight is lower than in wild-type transgenic mice but percentage is still higher than non-transgenic (non-diabetic) mice at 4 and 8 months

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:116040