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Phenotypes Associated with This Genotype
involves: C57BL/6 * CD-1 * DBA/2
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phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• transgenic islet cells show extensive DNA strand breaks compared to control islets
• proportion of insulin-producing cell mass to total pancreatic cell mass is markedly reduced at 4 weeks of age
• however, no infiltration of macrophages or lymphocytes (insulitis) is observed

• mice show hyperglycemia by one week of age with blood glucose above 400 mg/dl
• serum insulin level (0.53 ng/dl) is decreased compared to controls (3.68 ng/ml)
• urine often tested positive for ketones
• nitrite levels in medium, indicative of NO release, increase in a time-dependent manner
• treatment with aminoguanidine (inhibitor of Nos2) delays elevation of blood glucose levels and reduction in pancreatic insulin contents; reduction in insulin producing cell mass is reduced or improved with treatment
• urine glucose levels are 200-500 mg/dl by 1 week of age

renal/urinary system
• urine glucose levels are 200-500 mg/dl by 1 week of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory