Mouse Genome Informatics
tg
    Tg(Ins2-Nos2)40Okam/0
involves: C57BL/6 * CD-1 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
endocrine/exocrine glands
• proportion of insulin-producing cell mass to total pancreatic cell mass at 4 weeks of age
• transgenic islet cells show extensive DNA strand breaks compared to control islets

homeostasis/metabolism
• mice show hyperglycemia by one week of age with blood glucose above 400 mg/dl
• serum insulin level (0.53 ng/dl) is decreased compared to controls (3.68 ng/ml)
• serum insulin level (0.53 ng/dl) is decreased compared to controls (3.68 ng/ml)
• nitrite levels in medium, indicative of NO release, increase in a time-dependent manner
• treatment with aminoguanidine (inhibitor of Nos2) delays elevation of blood glucose levels and reduction in pancreatic insulin contents; reduction in insulin producing cell mass is reduced or improved with treatment
• urine glucose levels are 200-500 mg/dl by 1 week of age

renal/urinary system
• urine glucose levels are 200-500 mg/dl by 1 week of age

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:4552