Phenotypes Associated with This Genotype

Genotype
MGI:3704888

• Allelic Composition: Ucn3^tm1Pbl/Ucn3^tm1Pbl
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased insulin secretion ( J:119417 )

• in response to stimulation with high (16.8 mM) glucose levels islets produce less insulin compared to wild-type

decreased circulating insulin level ( J:119417 )

• on a high fat diet, mice exhibit decreased blood glucose levels compared to wild-type

improved glucose tolerance ( J:119417 )

• on a high fat diet, mice did not develop significant glucose intolerance, unlike wild-type mice

• at 12 - 13 months of age, glucose tolerance is improved compared to age-matched wild-type mice

• however, at 10-12 weeks of age no difference in glucose tolerance is detected

liver/biliary system

decreased susceptibility to diet-induced hepatic steatosis ( J:119417 )

• despite significant weight gain and increased fat mass in response to a high fat diet mice did not develop severe liver steatosis, unlike wild-type mice

endocrine/exocrine glands

decreased insulin secretion ( J:119417 )

• in response to stimulation with high (16.8 mM) glucose levels islets produce less insulin compared to wild-type