Phenotypes Associated with This Genotype

Genotype
MGI:3703795

• Allelic Composition: Man1a2^tm1.1Ahe/Man1a2^tm1.1Ahe
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Thick interalveolar septae and alveolar hemorrhaging in E18.5 Man1a2^tm1.1Ahe/Man1a2^tm1.1Ahe lungs

mortality/aging

neonatal lethality, complete penetrance ( J:119977 )

• neonates die within several hours of birth

respiratory system

pulmonary alveolar hemorrhage ( J:119977 )

• neonates exhibit alveolar hemorrhaging

• however, pulmonary capillary and blood vessel networks are normal

abnormal lung development ( J:119977 )

• lung development is delayed, with E18.5 and neonatal lungs at the canalicular stage of development instead of at the saccular stage, as in wild-type

abnormal pulmonary alveolus morphology ( J:119977 )

• decrease in alveolar air space at E18.5

atelectasis ( J:119977 )

• small isolated atelectactic regions are occasionally seen in the lungs, however all lungs inflate sufficiently to briefly sustain life (4-10 hours)

thick pulmonary interalveolar septum ( J:119977 )

• thickening of alveolar septae is seen at E18.5

respiratory distress ( J:119977 )

• within several hours of birth, progressively display signs of respiratory distress

cardiovascular system

pulmonary alveolar hemorrhage ( J:119977 )

• neonates exhibit alveolar hemorrhaging

• however, pulmonary capillary and blood vessel networks are normal

homeostasis/metabolism

cyanosis ( J:119977 )

• within several hours of birth, display signs of cyanosis